منابع مشابه
TRP channel proteins and signal transduction.
TRP channel proteins constitute a large and diverse family of proteins that are expressed in many tissues and cell types. This family was designated TRP because of a spontaneously occurring Drosophila mutant lacking TRP that responded to a continuous light with a transient receptor potential (hence TRP). In addition to responses to light, TRPs mediate responses to nerve growth factor, pheromone...
متن کاملNMR Approaches to Large Proteins: trp Repressor and Chloramphenicol Acetyltransferase
The current upper limit for protein structure determination by *H nmr [1] is in the region of Mr 12-15,000. The use of stable isotope labelling, with H, C or N, can substantially extend this limit, perhaps to Mr 30,000 (for methodological reviews, see [2][4]). However, there remain many interesting and important proteins which are much larger than this, and we have been trying to establish what...
متن کاملThe Role of TRP Proteins in Mast Cells
Transient receptor potential (TRP) proteins form cation channels that are regulated through strikingly diverse mechanisms including multiple cell surface receptors, changes in temperature, in pH and osmolarity, in cytosolic free Ca(2+) concentration ([Ca(2+)](i)), and by phosphoinositides which makes them polymodal sensors for fine tuning of many cellular and systemic processes in the body. The...
متن کاملTRP Is Cracked but Is CRAC TRP?
fly's compound eye. Unlike many genetically identified proteins in this system, which are enzymes in the phos-Mayo Foundation Rochester, Minnesota 55905 phatidylinositol pathway, TRP and TRPL were originally presumed to be ion channels based on their putative It takes only one close look at a housefly to tell you six transmembrane-spanning topology and the phenotype of the associated trp mutant...
متن کاملTRP channels.
The TRP (Transient Receptor Potential) superfamily of cation channels is remarkable in that it displays greater diversity in activation mechanisms and selectivities than any other group of ion channels. The domain organizations of some TRP proteins are also unusual, as they consist of linked channel and enzyme domains. A unifying theme in this group is that TRP proteins play critical roles in s...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 2001
ISSN: 0009-7330,1524-4571
DOI: 10.1161/01.res.88.3.256